Supplement bottle NAD+ and CA AKG
Three bottles of BetterMan Liposomal NAD+ with CA-AKG supplements
Multiple bottles of BetterMan NAD+ with CA AKG supplements

351+ Happy Customers

Liposomal NAD+ & CA-AKG

A high-strength liposomal NAD+ and Ca-AKG formula made to support cellular energy, DNA repair, brain health and healthy ageing from the inside out.

500mg high-dose NAD+ in a liposomal formula made for better absorption and delivery.

250mg Ca-AKG to support cellular energy, repair, recovery and long-term vitality.

Made to support DNA repair, brain health, oxidative stress defence and steady daily energy.
1 Jar
1 Jar
30 days supply
Best value
3 Jars
3 Jars
90 Days Supply
Save 24%
6 Jars
6 Jars
180 Days Supply
 
 
1 Jar
1 Jar
Accepted payment methods
Order in --h --m to be sent out today
Ordered
Processed
Posted
3 Jars
3 Jars
Accepted payment methods
Order in --h --m to be sent out today
Ordered
Processed
Posted
6 Jars
6 Jars
Accepted payment methods
Order in --h --m to be sent out today
Ordered
Processed
Posted

Harry Jones

Verified Customer ✅

I've loved the NAD+. I’ve been using this for about a month now and I'm feeling more switched on during the day, my energy feels steadier and I’m not getting that mid-afternoon slump like I usually do. I’ll definitely be keeping this in my routine.

OUR NUTRITIONALISTS RECOMMEND:

HOW DOES IT WORK?

Liposomal NAD+ & CA-AKG is built to support your body at cell level. NAD+ is found in every living cell and plays a major role in energy metabolism, DNA repair, gene expression and healthy ageing. In simple terms, it helps your cells do their job properly. The problem is that NAD+ levels naturally decline as you get older, which is why supporting them has become such a big part of the longevity conversation.

This formula uses liposomal technology to help protect NAD+ as it moves through the digestive system, so more of it reaches where it needs to go.

Ca-AKG is added because it works well alongside NAD+. It supports oxidative metabolism, cellular function, repair and recovery, making the formula more complete than a basic NAD+ supplement on its own. Proper cellular support for men who want better energy, sharper function and a body that keeps up.

IS IT FOR YOU?

This is for people who want to think a bit longer-term about their energy, ageing and daily performance.

Maybe you still get through the day, but you don’t feel as sharp as you used to. Maybe recovery feels slower, focus dips quicker or your energy doesn’t feel as steady. Or maybe you’re simply at the point where you want to support what’s going on under the surface, not just wait until something feels off.

Liposomal NAD+ & CA-AKG is made for those who care about energy, brain health, and healthy ageing. It’s not a quick buzz like caffeine. It’s not there to make wild promises. It’s daily support for the systems that help you feel switched on, steady and more like yourself for longer.

BENEFITS

Liposomal NAD+ & CA-AKG supports cellular energy, brain health and healthy ageing in one powerful formula.

The NAD+ side helps support the processes your cells rely on to produce energy and repair damage. That matters because when your cells are better supported, energy, focus and general vitality all have a stronger base to work from.

The Ca-AKG side adds support for metabolism, cellular function, repair and recovery. It’s one of the reasons this formula fits so well into a longevity routine, especially for men who want to stay sharp, active and capable as they get older.

INGREDIENTS LIST

Liposomal NAD+ — 500mg
Calcium Alpha-Ketoglutarate — 250mg

DELIVERY & RETURNS

BetterMan offers guaranteed 48-hour delivery for UK orders placed before 7am, so you can get your routine started quickly.

Payments are processed with bank-level security, and Liposomal NAD+ & CA-AKG is available in 1 jar, 3 jar and 6 jar options.

Unopened and sealed products can usually be returned within the legal cancellation period. Opened supplements cannot normally be returned for health and hygiene reasons.

Rated 4.7 on Trustpilot

Third-party Tested

4.9+ Satisfaction Score

Over 50,000 Customers

Next Day Delivery

How can Liposomal NAD+ & CA-AKG transform your energy?

A lot of us try to fix low energy from the outside in. More coffee. More pre-workout. Another early night that never actually happens. Liposomal NAD+ & CA-AKG works differently. It supports the cellular processes behind energy production, repair and healthy ageing, so your body has better support at the level that really matters.

NAD+ helps your cells produce usable energy and supports repair enzymes linked with DNA health. Ca-AKG helps support metabolism and cellular function, giving the formula a stronger long-term angle than a basic energy supplement.

The aim is not a short spike. It’s steadier support for energy, focus, recovery and feeling more switched on day to day.
 

Cellular Energy

NAD+ helps your cells turn nutrients into usable energy, which is why it matters so much when you feel flat, foggy or slower than usual. This liposomal formula is made to support NAD+ delivery, giving your body better backing for steady energy through the day.

DNA Repair Support

NAD+ helps activate repair enzymes like sirtuins and PARPs, which are involved in DNA repair and cellular maintenance. That makes it a smart supplement for men who care about healthy ageing, not just getting through today on caffeine and stubbornness.

Healthy Ageing

Ca-AKG supports oxidative metabolism, cellular function and repair, while NAD+ supports the energy and maintenance processes your cells depend on. Together, they’re made for men who want to stay sharper, stronger and better supported as they get older.

What To Expect When You Stick With It

9/10

Customers felt steadier energy day to day

84%

Of customers noticed better focus and clarity

4/5

Customers reported they felt less drained by mid-afternoon

88%

Of customers said they felt more switched on

Cellular Energy That Actually Goes Deeper

Liposomal NAD+ & CA-AKG is made for men who want energy support that starts where energy really starts: inside the cell.

Built For Energy, Repair And Longevity

Most energy supplements are only thinking about the next few hours. This is different. Liposomal NAD+ & CA-AKG is built around long-term cellular support. NAD+ helps back energy metabolism, DNA repair and healthy ageing. Ca-AKG helps support metabolism, repair, recovery and cellular function.

 

It’s high strength, liposomal and combined properly, so you’re not just taking another basic supplement and hoping for the best. No gimmicks. No fluff. Just a smarter formula for men who want to stay sharp, active and firing properly for longer.

BetterMan NAD+

Other

Oxidised NAD+

Active NAD+ form to support cellular energy and mitochondrial function

X

Added CA-AKG

Combined with powerful Calcium Alpha-Ketoglutarate

X

NAD+ Strength

High strength 500mg NAD+ serving

<400mg

Oxidised NAD+

Oxidised NAD+ is the form most associated with replenishment, cellular energy metabolism and healthy ageing research.

X

A Smarter Longevity Formula

Stay Sharp. Stay Confident.

"Low NAD levels impair mitochondrial function, which means your brain doesn't get the energy it needs. This leads to brain fog, slower thinking, and cognitive decline."

 

Dr Mark Hyman - Physician & Functional Medicine Leader

Liposomal NAD+ & CA-AKG FAQs

What is Calcium Alpha-Ketoglutarate (Ca-AKG) and why is it great?

Calcium Alpha-Ketoglutarate (Ca-AKG) is a stable, easily absorbed form of alpha-ketoglutarate—a compound naturally found in the body that plays a vital role in metabolism, cellular energy, and overall cellular function.

As we get older, our natural levels of AKG drop dramatically, which has prompted growing interest in supplementing it to help counteract some age-related changes.

AKG is known to support cellular regeneration and helps power essential processes during times of growth, repair, and recovery. It also contributes to protein metabolism and supports both digestive and kidney function.

By the age of 80, our AKG levels may fall to just 10% of what they were at 40, making supplementation a promising strategy for supporting long-term health and vitality.

The calcium-bound version, Ca-AKG, improves absorption and bioavailability—making it a practical and efficient way to access AKG’s potential benefits, which may include reduced frailty and improved overall wellness as we age.

A key 2020 study by Dr. Brian Kennedy and researchers at the Buck Institute for Research on Aging showed promising results for Calcium Alpha-Ketoglutarate (Ca-AKG) in extending health span and lifespan—in mice.

Ca-AKG extended median lifespan in mice by ~12% for females and ~10% for males.

Health span improvements were even more significant: the treated mice remained healthier and more active as they aged.

The compound appeared to reduce levels of systemic inflammation, a major driver of aging.

Mice supplemented with Ca-AKG looked and behaved younger, showing better posture, fur quality, and activity levels.

So, whilst it’s early days in the timeline of clinical studies, if these outcomes are replicated in humans, then we are looking at an extra 7-9 years of healthy life span.

How should I take this supplement?

It’s recommended to take the suggested serving daily, preferably with water or juice. Always follow the dosage instructions on the label or consult your healthcare provider before starting.

Why is liposomal NAD+ considered superior to NAC, NR, or NMN for longevity?

Liposomal NAD⁺ is considered more effective for longevity because it delivers NAD⁺ — the active form your body needs — directly and efficiently, bypassing the need for conversion steps that are required with precursors like NR (Nicotinamide Riboside) or NMN (Nicotinamide Mononucleotide). As we age, our bodies become less efficient at converting those precursors into usable NAD⁺, which can limit their effectiveness. NAC (N-acetyl cysteine), while beneficial, primarily supports glutathione production and doesn’t directly raise NAD⁺ levels. Liposomal delivery also enhances absorption by protecting NAD⁺ as it passes through the digestive tract, making it more bioavailable. This combination of direct action and enhanced uptake makes liposomal NAD⁺ a more reliable and potentially powerful option for those focused on supporting cellular health, energy, and longevity.

How long before I notice results?

Most users report improved energy, focus, and recovery within 2–4 weeks of consistent use. Results may vary depending on lifestyle, age, and overall health.

Is this product safe for everyone?

This supplement is generally safe for adults. However, if you are pregnant, nursing, have a medical condition, or take prescription medications, it’s best to consult your doctor before use.

When is the best time to take NAD+ with Ca-Akg?

NAD+ can sometimes affect sleep, though not for everyone. The main reason is timing. NAD+ plays a role in energy metabolism and circadian rhythm regulation, so if you take it too late in the day, it can make you feel more alert or restless at night.

A few people also report vivid dreams or lighter sleep when starting NAD+—possibly linked to increased mitochondrial activity or shifts in cellular repair cycles.

Most find it best taken in the morning, alongside food.

Clinical Studies

NAD+ for Cardiovascular Health

Human research published in Nature Communications found that nicotinamide riboside supplementation was well tolerated in healthy middle-aged and older adults and effectively increased NAD+ metabolism. The study also reported encouraging changes in markers linked to cardiovascular health, including blood pressure and arterial stiffness.
 

https://www.nature.com/articles/s41467-018-03421-7

Ca-AKG and Healthy Aging.

Preclinical research published in Cell Metabolism found that calcium alpha-ketoglutarate supplementation supported healthier ageing, with findings linked to increased lifespan for the mice as well as, reduced frailty and a shorter period of age-related decline.
 

https://pubmed.ncbi.nlm.nih.gov/32877690/

NAD+ and Healthy Aging

Human research published in Nature Communications found that high-dose nicotinamide riboside was well tolerated over four weeks and increased blood NAD+ levels by up to five-fold. This adds to the growing evidence base around NAD+ replenishment, cellular energy metabolism and age-related health research.
 

https://www.nature.com/articles/s41467-023-43514-6

Ca-AKG and Longevity + Biological Age Markers

A human retrospective study published in Aging found that an alpha-ketoglutarate-based formulation was associated with an average reduction of approximately eight years in DNA methylation biological age after around seven months of use.
 

https://www.aging-us.com/article/203736/text